Its mechanism of action is unknown, independent of its antiproliferative effect, although it seems related to the decrease in serum levels of cytokines and their receptors, as well as their inhibitory effect of leukocyte migration by release of adenosine from neutrophils, fibroblasts and cells Flekosteel.
It has long-term efficacy on the control of radiological progression and with a better toxicity profile than other drugs of this class. In addition, the use of MTX can be combined with that of tumor necrosis factor alpha (anti-TNF) blockers.
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